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Published on: April 20, 2017
Histamine containing endocrine cells in the human stomach
H Lönroth1, R Håkanson, L Lundell
1Department of Surgery, Sahlgren's Hospital, University of Gothenburg, Sweden.
Gut
|April 1, 1990
Summary
This study identifies histamine-containing endocrine cells in the human stomach. These cells, found in the oxyntic mucosa, are likely identical to enterochromaffin-like cells.
Area of Science:
- Gastroenterology
- Cell Biology
- Immunohistochemistry
Background:
- Histamine plays a role in gastric function.
- The identity and distribution of histamine-producing cells in the human stomach require clarification.
Purpose of the Study:
- To investigate the presence and characteristics of histamine-immunoreactive cells in the human gastric mucosa.
- To determine the relationship between histamine-containing cells and chromogranin A-immunoreactive cells.
Main Methods:
- Double immunostaining techniques were employed.
- Antibodies against histamine and chromogranin A were used.
- Cellular localization within the gastric mucosa was analyzed.
Main Results:
- Histamine and chromogranin A-immunoreactive cells were identified in the human stomach.
- These double-labeled cells, termed histamine-containing endocrine cells, were localized to the oxyntic mucosa.
- 22% of histamine-immunoreactive cells in the oxyntic gland area also stained for chromogranin A.
- Histamine-containing endocrine cells represented 44% of all endocrine cells in the oxyntic mucosa.
Conclusions:
- The histamine-containing endocrine cells in the human stomach are likely identical to enterochromaffin-like (ECL) cells.
- This finding clarifies the cellular source of histamine in the gastric mucosa.
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