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A digital microfluidic method for dried blood spot analysis.

Mais J Jebrail1, Hao Yang, Jared M Mudrik

  • 1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

Lab on a Chip
|August 27, 2011
PubMed
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Dried blood spot (DBS) analysis is advancing with a new microfluidic system for automated amino acid quantification. This innovative method enhances speed, precision, and robustness for widespread application in biological sample analysis.

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Microfluidics

Background:

  • Dried blood spots (DBSs) are increasingly popular for biological sample storage and analysis.
  • Current automated extraction and analysis techniques for DBS samples lag behind their growing application.
  • There is a need for improved, automated methods for quantifying analytes in DBS.

Purpose of the Study:

  • To develop a prototype microfluidic system for the automated quantification of amino acids in dried blood spots.
  • To create a method compatible with automation for DBS analysis.
  • To establish a foundation for next-generation analytical techniques for DBS.

Main Methods:

  • Development of a prototype microfluidic system for DBS analysis.
  • Integration of analyte extraction, internal standard mixing, derivatization, and reconstitution within the microfluidic device.

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  • Analysis of reconstituted analytes using off-line and in-line tandem mass spectrometry.

    • Main Results:

    • The developed microfluidic system enables automated quantification of amino acids from DBS samples.
    • The method demonstrated speed, robustness, and precision.
    • The system is compatible with automation, paving the way for high-throughput analysis.

    Conclusions:

    • The prototype microfluidic system represents a significant step towards automated DBS analysis.
    • This technology can potentially lead to a new generation of analytical techniques for quantifying various analytes in DBS.
    • The method offers a fast, precise, and robust approach for amino acid quantification in DBS samples.