Related Experiment Video

Updated: May 29, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

No association between herpes simplex virus 1 and cardiac myxoma

Ulrich P Schurr1, Denis A Berdajs, Beate Bode

  • 1Department of Cardiac Surgery, Triemli Hospital, Zürich, Switzerland. Ulrich.Schurr@triemli.stzh.ch

Swiss Medical Weekly
|August 27, 2011
PubMed

Insights

This study investigated the link between herpes simplex virus 1 (HSV-1) and cardiac myxoma. Researchers found no evidence of HSV-1 infection in cardiac myxoma tissues, suggesting it is not a contributing factor.

Area of Science:

  • Cardiology
  • Oncology
  • Virology

Background:

  • Cardiac myxoma is the most common primary cardiac tumor.
  • Herpes simplex virus 1 (HSV-1) has been previously suggested as a potential factor in cardiac myxoma development.
  • This study aimed to investigate the association between HSV-1 and cardiac myxoma.

Purpose of the Study:

  • To determine if HSV-1 infection is associated with the occurrence of cardiac myxoma.
  • To evaluate the role of HSV-1 in the pathogenesis of cardiac myxoma.

Main Methods:

  • A cohort of 70 patients who underwent cardiac myxoma resection between 1965 and 2005 was studied.
  • Tumor biopsies from 40 patients were analyzed using immunohistochemistry for HSV-1 antigens.
  • Clinical data, including mortality, morbidity, and follow-up, were collected and analyzed.

Main Results:

  • No positive signals for HSV-1 antigens were detected in the analyzed cardiac myxoma tissues.
  • The study observed low peri-operative morbidity and mortality over a 40-year period.
  • Complete surgical resection, including the septum, was confirmed as essential for preventing recurrence.

Conclusions:

  • There is no evidence to support an association between HSV-1 infection and the occurrence of cardiac myxoma.
  • Complete surgical resection remains the gold standard treatment for cardiac myxoma to prevent relapses.
  • Long-term follow-up indicates favorable outcomes with low morbidity and mortality after surgical intervention.
Abstract

More Related Videos

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 111:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...