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Related Experiment Videos

Gonadotrophin glycosylation and function.

C A Wilson1, A J Leigh, A J Chapman

  • 1Department of Obstetrics and Gynaecology, St George's Hospital Medical School, London.

The Journal of Endocrinology
|April 1, 1990
PubMed
Summary
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The structure and charge of gonadotrophin oligosaccharides significantly impact hormone bioactivity and potency. Hormone isoforms vary in potency and circulation time, influencing in vitro and in vivo activity.

Area of Science:

  • Endocrinology
  • Glycobiology
  • Reproductive Biology

Background:

  • Gonadotrophins are crucial hormones regulating reproductive functions.
  • The structure of gonadotrophins, particularly their oligosaccharide chains, is complex and heterogeneous.
  • Variations in gonadotrophin structure are linked to changes in bioactivity and potency.

Purpose of the Study:

  • To review the influence of oligosaccharide structures on gonadotrophin bioactivity.
  • To summarize changes in gonadotrophin biopotency across the human life-cycle and in rat endocrine states.
  • To explore the impact of gonadotrophin-releasing hormone (GnRH) and gonadal steroids on gonadotrophin isoforms.

Main Methods:

  • Literature review focusing on gonadotrophin structure-function relationships.

Related Experiment Videos

  • Analysis of data on biopotency changes throughout the life-cycle and in different endocrine states.
  • Examination of the effects of GnRH and gonadal steroids on gonadotrophin glycosylation and sialylation.

    • Main Results:

    • Hormone charge, determined by oligosaccharide terminal groups, strongly influences biopotency.
    • Basic gonadotrophin isoforms show higher in vitro potency but shorter half-lives; acidic isoforms have lower in vitro potency but longer circulatory times.
    • Hormone isoforms secreted vary with age and reproductive status, with more basic forms in adulthood.
    • Glycosyl structure changes in different endocrine states, affecting bioactivity.
    • GnRH enhances glycosylation, sulphation, and biopotency; oestradiol potentiates GnRH-induced glycosylation and reduces sialylation; testosterone increases sialylation.

    Conclusions:

    • Oligosaccharide structure and charge are critical determinants of gonadotrophin bioactivity and potency.
    • The balance of basic and acidic gonadotrophin isoforms influences in vivo and in vitro activity.
    • Hormonal regulation, including GnRH and gonadal steroids, modulates gonadotrophin isoform synthesis and release, impacting reproductive function.