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Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Related Experiment Video

Updated: May 29, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

[Modification of collagen during action light].

G A Rebrova, V A Bykov, L A Osipova

    Biomeditsinskaia Khimiia
    |August 30, 2011
    PubMed
    Summary

    Visible light causes chemical changes in collagen, indicating photodegradation and photooxidation. This study reveals how sunlight affects collagen structure and stability.

    Area of Science:

    • Biochemistry
    • Materials Science

    Context:

    • Collagen is a crucial structural protein in connective tissues.
    • Understanding collagen's response to environmental factors is vital for biomaterials and tissue engineering.

    Purpose:

    • To investigate the chemical modifications of collagen induced by visible spectrum sunlight.
    • To identify the specific photodegradation and photooxidation pathways involved.

    Summary:

    • Chemical modification of collagen was observed upon exposure to visible light.
    • These alterations signify photodegradation and photooxidation processes within the collagen structure.

    Impact:

    • Provides insights into the stability of collagen-based materials under light exposure.

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    Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization
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    Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization

    Published on: September 29, 2015

    Related Experiment Videos

    Last Updated: May 29, 2026

    Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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    Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

    Published on: January 31, 2014

    Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
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    Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

    Published on: May 9, 2016

    Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization
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    Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization

    Published on: September 29, 2015

  • Contributes to understanding the aging process of biological tissues and biomaterials.