Optimization of topical gels with betamethasone dipropionate: selection of gel forming and optimal cosolvent system
Mariana Băiţan1, Mihaela Lionte, Lăcrămioara Moisuc
1Research and Development Department, Antibiotice SA, Iaşi, Romania Gr. T. Popa University of Medicine and Pharmacy Iaşi School of Pharmacy.
Abstract:
The purpose of these studies was to develop a 0.05% betamethasone gel characterized by physical-chemical stability and good release properties. The preliminary studies were designed to select the gel-forming agents and the excipients compatible with betamethasone dipropionate. In order to formulate a clear gel without particles of drug substances in suspension, a solvent system for the drug substance was selected. The content of drug substance released, the rheological and in vitro release tests were the tools used for the optimal formulation selection. A stable carbomer gel was obtained by solubilization of betamethasone dipropionate in a vehicle composed by 40% PEG 400, 10% ethanol and 5% Transcutol.
