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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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Catalytic intermolecular hetero-dehydro-Diels-Alder cycloadditions: regio- and diasteroselective synthesis of

Jesús Manuel Fernández-García1, Manuel Á Fernández-Rodríguez, Enrique Aguilar

  • 1Instituto Universitario de Química Organometálica Enrique Moles, Universidad de Oviedo, C/Julián Clavería, 8, 33006 Oviedo, Asturias, Spain.

Organic Letters
|August 30, 2011
PubMed

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Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...