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Related Concept Videos

Colloids and Suspensions01:17

Colloids and Suspensions

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Centrifugation01:05

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles
12:47

Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles

Published on: October 4, 2012

Voluven, a new colloid solution.

Anna Mizzi1, Thanh Tran, Rachel Karlnoski

  • 1Department of Cardiothoracic and Vascular Anesthesia, San Raffaele Hospital, "Vita e Salute" University, Milan, Italy.

Anesthesiology Clinics
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Hydroxyethyl starch (HES) 130/0.4, known as Voluven, effectively treats hypovolemia. Its smaller molecule size allows safe use in renal impairment with fewer coagulation effects than other HES products or albumin.

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Area of Science:

  • Pharmacology
  • Critical Care Medicine
  • Nephrology

Background:

  • Hypovolemia requires effective volume expansion therapies.
  • Hydroxyethyl starch (HES) products are commonly used for fluid resuscitation.
  • Renal impairment and coagulopathy are critical considerations in patient management.

Purpose of the Study:

  • To evaluate the safety and efficacy of Hydroxyethyl starch (HES) 130/0.4 (Voluven).
  • To compare Voluven's pharmacokinetic and hemodynamic profile with other HES products and albumin.
  • To assess Voluven's suitability in patients with renal impairment and coagulopathy risks.

Main Methods:

  • Review of existing clinical studies and pharmacokinetic data for Voluven.
  • Comparative analysis of volume expansion effects and hemodynamic stability.
  • Assessment of coagulation parameters and plasma accumulation.

Main Results:

  • Voluven exhibits less plasma accumulation due to its smaller molecular size compared to other HES products.
  • Voluven demonstrates comparable volume expansion and hemodynamic effects to other HES solutions.
  • Voluven is associated with fewer adverse effects on coagulation, making it a safer alternative in specific patient populations.

Conclusions:

  • Voluven is indicated for hypovolemia treatment and prophylaxis.
  • Its favorable pharmacokinetic profile allows safe use in patients with renal impairment.
  • Voluven presents a viable alternative to albumin for volume expansion, especially when coagulopathy is a concern.