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Updated: May 29, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Dopamine D1 receptor antagonism impairs extinction of cocaine-cue memories
Ashley N Fricks-Gleason1, Anna J Khalaj, John F Marshall
1University of California, Irvine. Department of Neurobiology & Behavior, 2205 McGaugh Hall, Irvine, CA 92697-4550, USA.
Abstract:
Increasingly, research suggests a role for dopamine D1 receptors in the consolidation of extinction of both appetitive and aversive memories. However, a role for D1 receptors in extinction of memories involving drug reward has yet to be established. Here we show that post-retrieval, but not delayed, systemic administration of the D1 receptor antagonist SCH23390 results in prolonged extinction of cocaine conditioned place preference (CPP), suggesting a critical role for D1 receptors in the consolidation of extinction of cocaine-cue memories.
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