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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems.

J F Almeida1, P Ferreira, A Lopes

  • 1Department of Chemical Engineering, University of Coimbra, Rua Sílvio Lima, Polo II, 3030-790 Coimbra, Portugal.

International Journal of Biological Macromolecules
|August 30, 2011
PubMed
Summary

Researchers developed novel dextran-based graft polymer hydrogels for controlled drug release. These biocompatible materials show promise for biomedical applications, offering tunable properties for efficient drug encapsulation and delivery.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Controlled release from biocompatible materials is crucial for biomedical applications.
  • Dextran-based glucopyranosides are promising due to biocompatibility and biodegradability.
  • Regulating rheological properties and release efficiency is key for dextran applications.

Purpose of the Study:

  • To prepare and characterize graft polymer hydrogels from dextran and N-isopropylacrylamide (NIPAAm).
  • To investigate the potential of these hydrogels for controlled drug release applications.
  • To evaluate the influence of temperature on drug release profiles.

Main Methods:

  • Graft polymer hydrogels synthesized by modifying dextran with 2-isocyanatoethylmethacrylate (IEMA) and UV crosslinking.
  • Characterization using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, elemental analysis, and contact angle measurements.
  • Drug (Ondansetron) encapsulation and release studies at 25°C and 37°C, alongside swelling behavior and Lower Critical Solution Temperature (LCST) determination.

Main Results:

  • Successful synthesis of dextran-NIPAAm graft polymer hydrogels with urethane linkages.
  • Characterization confirmed the successful modification and crosslinking of the polymer structure.
  • Ondansetron release profiles were determined, showing temperature-dependent release behavior.

Conclusions:

  • Dextran-NIPAAm graft polymer hydrogels are viable biocompatible materials for controlled drug delivery.
  • The developed hydrogels offer tunable properties suitable for biomedical applications.
  • Further research can explore optimization for specific therapeutic needs.