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Published on: October 12, 2016
Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice
Qing Yan1, Jiasong Guo, Xuebao Zhang
1Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Journal of the Neurological Sciences
|August 30, 2011
Summary
Fig4 haploinsufficiency does not increase neuronal degeneration risk in mice, even after sciatic nerve injury. This study found no evidence that reduced FIG4 function exacerbates motor neuron damage under trauma conditions.
Area of Science:
- Neuroscience
- Genetics
- Cell Biology
Background:
- FIG4 mutations cause neuronal degeneration in pale-tremor (plt) mice and Charcot-Marie-Tooth disease type 4J (CMT4J).
- Minor trauma accelerates motor neuron degeneration in CMT4J patients.
- Heterozygous FIG4 loss is a potential risk factor for sporadic amyotrophic lateral sclerosis.
Purpose of the Study:
- To investigate if minor trauma triggers or worsens motor neuron degeneration in mice with fig4 haploinsufficiency (plt+/-).
Main Methods:
- Studied 18 wild-type and 18 plt+/- mice.
- Induced nerve injury by sciatic nerve compression.
- Evaluated outcomes using nerve conduction studies, Rotarod tests, and nerve morphology.
Main Results:
- No significant differences were observed between wild-type and plt+/- mice in any tested condition.
- Sciatic nerve injury did not lead to increased neuronal degeneration in fig4 haploinsufficient mice.
Conclusions:
- Haploinsufficiency of FIG4 does not confer increased risk for neuronal degeneration in rodents, neither in normal conditions nor following traumatic injury.
