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Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Related Experiment Video

Updated: May 29, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Thrombin generation in severe sepsis.

S Petros1, P Kliem, T Siegemund

  • 1University Hospital Leipzig, Medical ICU, Leipzig, Germany. Sirak.Petros@uniklinik-leipzig.de

Thrombosis Research
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Thrombin peak levels in severe sepsis correlate with survival, while faster thrombin generation may indicate disseminated intravascular coagulation (DIC). Endogenous thrombin potential did not predict outcomes in sepsis patients.

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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Last Updated: May 29, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Published on: February 27, 2026

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model
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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Area of Science:

  • Coagulation and Thrombosis
  • Sepsis Pathophysiology
  • Inflammation and Immunity

Background:

  • Hemostasis and inflammation are interconnected host responses to infection.
  • Thrombin generation significantly influences inflammation during sepsis.
  • Understanding thrombin's role in sepsis is crucial for predicting patient outcomes.

Purpose of the Study:

  • To investigate the temporal profile of thrombin generation in severe sepsis.
  • To correlate thrombin generation parameters with patient survival in severe sepsis.
  • To assess the prognostic value of thrombin generation assays in sepsis.

Main Methods:

  • Calibrated Automated Thrombography (CAT) was used to measure thrombin generation in platelet-poor plasma.
  • Plasma samples were collected from 75 severe sepsis patients at multiple time points and 32 healthy controls.
  • Thrombin generation was assessed with and without thrombomodulin, alongside clinical data collection.

Main Results:

  • Significant differences in peak thrombin, lag time, and time to peak thrombin were observed between sepsis patients and controls.
  • Higher thrombin peak levels were associated with survival, particularly at later time points (t2, t4).
  • Shorter lag times and time to thrombin peak were observed in non-survivors, suggesting potential disseminated intravascular coagulation (DIC).

Conclusions:

  • Thrombin peak levels demonstrate a positive correlation with survival in severe sepsis.
  • Lag phase and time to thrombin peak may serve as indicators of impending DIC.
  • Endogenous thrombin potential lacks prognostic significance in severe sepsis outcomes.