Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep lowers waking theta frequency in the rat hippocampus.

Cell reports·2026
Same author

Genetic inactivation of Translin/Trax RNase disrupts miRNAs, hippocampal synaptic plasticity, and memory.

iScience·2026
Same author

Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder.

Current psychiatry reports·2026
Same author

Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning.

Communications biology·2026
Same author

Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.

Molecular brain·2026
Same author

Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model.

Brain, behavior, and immunity·2026

Related Experiment Video

Updated: May 29, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Aging impairs hippocampus-dependent long-term memory for object location in mice.

Mathieu E Wimmer1, Pepe J Hernandez, Jennifer Blackwell

  • 1Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

Neurobiology of Aging
|August 30, 2011
PubMed
Summary

Aging impairs long-term spatial memory in mice, particularly hippocampus-dependent functions like navigation. This cognitive decline affects the quality of life for older adults and their families.

More Related Videos

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze
06:09

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Published on: July 17, 2017

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
05:57

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Related Experiment Videos

Last Updated: May 29, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze
06:09

Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Published on: July 17, 2017

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
05:57

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Cognitive decline is a significant issue in aging, impacting quality of life.
  • Hippocampus-dependent functions, such as spatial navigation, are particularly vulnerable to aging.
  • Studying cognitive changes in aged animals is challenging due to motor and stress response alterations.

Purpose of the Study:

  • To investigate the impact of aging on long-term spatial memory in mice.
  • To assess spatial memory using a hippocampus-dependent object-place recognition task.
  • To differentiate age-related spatial memory deficits from general recognition abilities.

Main Methods:

  • Utilized an object-place recognition task to assess hippocampus-dependent spatial memory.
  • Compared the performance of aged mice with young adult mice.
  • Employed a control object recognition task to exclude non-hippocampal confounds.

Main Results:

  • Aged mice demonstrated significant impairment in long-term spatial memory.
  • Performance on the object-place recognition task was notably reduced in aged subjects.
  • Aged mice performed comparably to young adults on a non-hippocampal object recognition task.

Conclusions:

  • Long-term spatial memory is demonstrably impaired in aged mice.
  • Aging specifically affects hippocampus-dependent memory functions.
  • These findings highlight the vulnerability of spatial memory to the aging process.