Related Experiment Video
Updated: May 29, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Recurrence of angina pectoris after percutaneous coronary intervention is reduced by statins in Japanese patients
Ryusuke Tsunoda1, Tomohiro Sakamoto, Sunao Kojima
1Division of Cardiology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Insights
Statin therapy after percutaneous coronary intervention (PCI) significantly reduced cardiovascular events, especially recurrent angina. This highlights statins
Area of Science:
- Cardiology
- Pharmacology
Background:
- Statins are known to reduce cardiovascular events in coronary artery disease (CAD).
- Percutaneous coronary intervention (PCI) is a common treatment for CAD symptoms.
- Limited data exists on statin efficacy post-PCI, especially with coronary stent implantation.
Purpose of the Study:
- To evaluate the effect of statin therapy on cardiovascular events after PCI.
- To assess statin impact on restenosis and recurrent angina in CAD patients.
Main Methods:
- 1019 patients with CAD and moderate cholesterol were randomized to statin or no statin treatment.
- The primary endpoint included cardiovascular death, myocardial infarction, recurrent angina, heart failure, and stroke.
- Follow-up was for 2 years, with coronary angiography to assess restenosis.
Main Results:
- Statin use reduced the primary endpoint event rate from 14.7% to 9.5% (p=0.0292).
- Statins significantly suppressed recurrent angina (rAP) (p=0.0027).
- Coronary angiography showed statins reduced restenosis but not new lesion formation in patients with rAP.
Conclusions:
- Statin therapy is effective in reducing cardiovascular events, particularly recurrent angina, in Japanese CAD patients undergoing PCI with stent implantation.
- Achieving low-density lipoprotein cholesterol (LDL-C) levels below 100 mg/dl with statins effectively reduced restenosis causing recurrent angina.
Background:
Statins have been reported to reduce cardiovascular events in patients with coronary artery disease (CAD). Percutaneous coronary intervention (PCI) is commonly used to relieve ischemic symptoms in patients with CAD. However, there is little information on the effect of statins on cardiovascular events after PCI, even in the era of coronary stent implantation.
Methods:
A total of 1019 patients with acute or chronic CAD and modest total cholesterol levels (180-240 mg/dl) were enrolled and randomly assigned to treatment with or without statins. We evaluated the effect of any available statin on the incidence of cardiovascular events after PCI. The primary endpoint was a composite of cardiovascular death, nonfatal acute myocardial infarction (MI), recurrent angina pectoris requiring emergency rehospitalization (rAP), heart failure, and stroke.
Results:
Indications for PCI were stable angina in 54%, ST-elevation MI in 41% and non-ST-elevation MI/unstable angina pectoris in 5%. After 2 years of statin treatment, low-density lipoprotein cholesterol (LDL-C) decreased from 133 to 96 mg/dl. Stents were implanted in 84% of all cases. The primary endpoint event rate was 9.5% in the statin group and 14.7% in the non-statin group (p=0.0292). Of all primary endpoint events, only rAP was significantly suppressed by statins (p=0.0027). In rAP patients, coronary angiography revealed that statins suppressed restenosis but not new lesions.
Conclusions:
For Japanese CAD patients treated with PCI and stent implantation, statin therapy reduced the incidence of recurrent cardiovascular events, particularly rAP. Discretionary statin treatment to achieve LDL-C levels <100 mg/dl effectively reduced restenosis causing rAP.
Related Concept Videos
01:26Angina IV: Management
01:27Coronary Artery Disease V: Interprofessional Care
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:26Atherosclerosis III: Management
01:20Angina V: Nursing Management
01:27Peripheral Artery Disease III: Interprofessional Care