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Developing HiPSC Derived Serum Free Embryoid Bodies for the Interrogation of 3-D Stem Cell Cultures Using Physiologically Relevant Assays
Published on: July 20, 2017
Embryonic stem cells and iPS cells: sources and characteristics
Catherine H Hackett1, Lisa A Fortier
1Department of Clinical Sciences, Box 32, Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Abstract:
The field of regenerative medicine research is rapidly expanding. One area of interest to equine researchers is the possibility of isolating or generating pluripotent cells, capable of producing differentiated cell types derived from all 3 primary germ layers. Reports of equine embryonic stem-like (ES) cell isolation can be found in the literature. Other groups are working to produce equine-induced pluripotent stem (iPS) cells. This article summarizes the essential features needed to characterize a cell type as pluripotent, specific challenges in using the horse as a model organism for pluripotent cell generation, and current and upcoming clinical trials using ES/iPS cells.
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