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Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery
Ali Movafegh1, Laleh Eslamian, Azita Dorabadi
1Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objective:
To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.
Methods:
One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.
Results:
The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).
Conclusion:
Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
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