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Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

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Published on: October 27, 2020

Visceral adiposity after tibolone use.

Sebastián Carranza-Lira¹, Tomás D Bárcena-Jacobo, Martha P Sandoval-Barragán

¹Gynecology and Obstetrics Hospital Luis Castelazo Ayala, Social Security Mexican Institute, Mexico City, Mexico. scarranzal@mexis.com

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics

|August 30, 2011

Summary

Tibolone use in postmenopausal women is associated with reduced visceral fat. This study found significantly lower visceral fat measurements in women taking tibolone compared to those not using it.

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Area of Science:

Endocrinology
Menopause Research
Body Composition Analysis

Background:

Tibolone is a synthetic steroid used for hormone replacement therapy in postmenopausal women.
Visceral fat accumulation is a health concern in postmenopause, linked to metabolic and cardiovascular diseases.

Purpose of the Study:

To compare visceral fat levels in postmenopausal women using tibolone versus those not using it.

Main Methods:

A study involving 65 healthy postmenopausal women: 26 on tibolone (2.5 mg/day) and 39 controls.
Anthropometric measurements, including subcutaneous and visceral fat via ultrasound.
Statistical analysis using Student's t-test to compare groups.

Main Results:

No significant differences in age, weight, BMI, or waist circumference between groups.
Significantly lower hip circumference, visceral fat measurements, and visceral fat-to-subcutaneous fat ratio in the tibolone group.
No significant difference in subcutaneous fat measurements.

Conclusions:

Postmenopausal women using tibolone demonstrate reduced visceral fat compared to non-users.
Tibolone may play a role in modulating body composition, specifically reducing harmful visceral fat accumulation.