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Prenyl proteins in eukaryotic cells: a new type of membrane anchor
J A Glomset1, M H Gelb, C C Farnsworth
1Howard Hughes Medical Institute Laboratory, Department of Medicine, University of Washington, Seattle 98195.
Trends in Biochemical Sciences
|April 1, 1990
Abstract:
Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.