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Published on: February 9, 2021
Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles
Dalip Kumar1, N Maruthi Kumar, Kuei-Hua Chang
1Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, India. dalipk@bits-pilani.ac.in
Bioorganic & Medicinal Chemistry Letters
|August 30, 2011
Abstract:
A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a-n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity.
