Related Experiment Video
Updated: May 29, 2026
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Peripapillary subretinal neovascular membranes: a review
1Veterans Affairs Greater Los Angeles Healthcare System, California, USA.
Abstract:
Peripapillary subretinal neovascular membranes (PSRNVM) are most commonly associated with age-related macular degeneration and idiopathic causes in older patients. In younger patients, the condition has been linked to a wide variety of other conditions. As with the more commonly occurring macular form of choroidal neovascular membranes, PSRNVM can also lead to severe vision loss. Therefore, clinicians must take care to avoid overlooking this event to provide appropriate management and treatment. Current knowledge of PSRNVM suggests the importance of regular examinations of the affected eye in both treated and untreated cases to watch for progression and recurrence, which are unpredictable, and also of the fellow eye because there is a high risk of bilateral involvement.
Insights
Peripapillary subretinal neovascular membranes (PSRNVM) can cause vision loss in patients of all ages. Early detection and regular monitoring are crucial for managing this condition and its potential recurrence.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neovascularization
Background:
- Peripapillary subretinal neovascular membranes (PSRNVM) are a significant cause of vision impairment.
- While often linked to age-related macular degeneration, PSRNVM can occur in younger individuals due to various underlying conditions.
Purpose of the Study:
- To highlight the importance of recognizing and managing peripapillary subretinal neovascular membranes.
- To emphasize the need for vigilant monitoring for progression, recurrence, and bilateral involvement.
Main Methods:
- This study reviews current knowledge and clinical implications of PSRNVM.
- It emphasizes the importance of regular ophthalmic examinations for affected and fellow eyes.
Main Results:
- PSRNVM, similar to macular choroidal neovascularization, can lead to severe vision loss.
- Unpredictable progression and recurrence necessitate ongoing monitoring.
- There is a high risk of bilateral involvement, underscoring the need for fellow eye examination.
Conclusions:
- Clinicians must be vigilant in diagnosing PSRNVM to ensure timely and appropriate management.
- Regular follow-up examinations are essential for both treated and untreated cases to monitor for disease activity.
- Proactive monitoring of the fellow eye is critical due to the significant risk of bilateral disease.
