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Updated: May 29, 2026

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
07:26

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes

Published on: October 15, 2016

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains.

Xinxin Gao1, Pamela R Lowry, Xin Zhou

  • 1Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Proceedings of the National Academy of Sciences of the United States of America
|August 30, 2011
PubMed
Summary

Spatial compartmentalization is key for the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Proper localization of key proteins in membrane rafts is essential for signal transduction and preventing conditions like insulin resistance.

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