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Updated: May 29, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Isoniazid-induced recurrent acute pancreatitis.
Arvind S Pandey1, Ashish Surana
1Department of Tuberculosis and Respiratory Diseases, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.
Tropical Doctor
|August 30, 2011
Summary
Drug-induced acute pancreatitis is a potential complication of antitubercular therapy. Early recognition and isoniazid withdrawal can reverse this condition, as demonstrated by a case of reversible pancreatitis.
Area of Science:
- Gastroenterology
- Pharmacology
- Infectious Diseases
Background:
- Antitubercular drugs are essential for treating tuberculosis but can cause adverse effects.
- Drug-induced acute pancreatitis is an uncommon but serious complication.
- Isoniazid is a first-line antitubercular medication with a known risk profile.
Observation:
- Acute abdomen symptoms developed shortly after initiating antitubercular treatment.
- A patient presented with acute pancreatitis attributed to isoniazid therapy.
- Pancreatitis resolved upon discontinuation of isoniazid.
Findings:
- Isoniazid-induced pancreatitis is potentially reversible.
- Recurrence of pancreatitis was observed upon reintroduction of isoniazid.
- This highlights the causal link between isoniazid and pancreatitis.
Implications:
- Clinicians should consider drug-induced pancreatitis in patients on antitubercular treatment presenting with acute abdominal pain.
- Prompt recognition and withdrawal of the offending agent, isoniazid, are crucial for patient recovery.
- This case underscores the importance of vigilant monitoring for adverse drug reactions during tuberculosis treatment.
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