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[Primary central nervous system lymphomatoid granulomatosis: a case report]
Kenji Kagawa1, Tsuyoshi Ishida, Hitoshi Okada
1Department of Neurosurgery, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa-city, Chiba, Japan.
No Shinkei Geka. Neurological Surgery
|August 30, 2011
Summary
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated brain disease. This case highlights LYG as a rare cause of brain lesions, emphasizing the need for histopathology in diagnosis.
Area of Science:
- Neurology
- Pathology
- Oncology
Background:
- Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated lymphoproliferative disorder.
- LYG typically affects multiple organs but can rarely present as isolated central nervous system disease.
Observation:
- A 57-year-old man presented with visual disturbance due to an enhancing lesion in the left occipital lobe.
- MRI revealed an irregular, partly cystic, and lobulated enhancement, mimicking neoplastic lesions.
Findings:
- Surgical resection and histopathological examination revealed angiocentric, angiodestructive infiltration with atypical lymphocytes.
- Immunohistochemistry and Epstein-Barr virus encoded small RNA (EBER) in situ hybridization confirmed LYG, with EBER positivity in atypical cells.
Implications:
- This case underscores the importance of considering LYG in the differential diagnosis of ring-enhancing brain lesions.
- Accurate histopathological diagnosis is crucial for appropriate treatment strategies in rare neurological conditions like LYG.
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