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Investigating potential physicochemical errors in polymer gel dosimeters.

Mahbod Sedaghat1, Rachel Bujold, Martin Lepage

  • 1Centre d'imagerie moléculaire de Sherbrooke, Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, QC, Canada.

Physics in Medicine and Biology
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Heat released during polymer gel dosimetry irradiation does not affect dose response if oxygen is removed. However, some new gels show pre-irradiation instability without geometric distortion.

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Area of Science:

  • Medical Physics
  • Polymer Science

Background:

  • Polymer gel dosimeters are used in radiation therapy to measure absorbed dose.
  • The exothermic polymerization reaction can potentially affect dose response and cause geometric distortions.

Purpose of the Study:

  • To investigate the effect of heat from exothermic polymerization on polymer gel dosimeter dose response.
  • To determine if heat-generated geometric distortions occur in thermoresponsive polymer gels.
  • To compare dose measurements in small calibration vials versus larger phantoms.

Main Methods:

  • Studied the dose response of polymer gel dosimeters under varying temperature conditions.
  • Investigated the presence of geometric distortions in newly developed gel dosimeters.
  • Compared data from small calibration vials with data from larger phantoms.

Main Results:

  • Significant internal temperature increases did not affect dose response when oxygen was mechanically expelled.
  • Pre-irradiation instability was observed in some new polymer gel dosimeters.
  • No significant geometric distortions were observed in the studied gel dosimeters.

Conclusions:

  • Mechanical oxygen expulsion is crucial for maintaining dose response accuracy in polymer gel dosimetry.
  • Newer polymer gel formulations may exhibit pre-irradiation instability requiring careful handling.
  • Discrepancies between small vial and large phantom measurements may stem from physicochemical factors.