Related Experiment Video
Updated: May 29, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
Fibromyalgia symptoms, physical function, and comorbidity in middle-aged and older adults
Casey R Shillam1, Kim Dupree Jones, Lois Miller
1Betty Irene Moore School of Nursing, University of California, Davis, Sacramento, CA 95817, USA. casey.shillam@ucdmc.ucdavis.edu
Background:
Multiple studies report on symptoms or physical function in people with fibromyalgia; however, limited studies have been focused on older adults with fibromyalgia.
Objectives:
The aims of this study were to describe the occurrence, frequency, severity, and distress of symptoms and to examine differences in symptoms and physical function between a middle-aged and an older group.
Method:
Questionnaires were mailed to a random sample of 533 adults with fibromyalgia over 50 years of age, using a large tertiary care database. These questionnaires included an investigator-developed 29-item symptom questionnaire that measured the frequency (1-4), severity (1-4), and distress (0-4) of FM symptoms. The participants also completed the Late Life Function and Disability Instrument and the Charlson Comorbidity Index.
Results:
Fifty-three percent of the sample reported at least 20 symptoms in the last 7 days. The most frequent and severe symptoms were pain, nonrefreshing sleep, fatigue, stiffness, difficulty staying asleep, difficulty falling asleep, and profuse sweating. The most distressing symptoms were fear of symptoms worsening, followed by difficulty staying asleep, fatigue, nonrefreshing sleep, and restless legs. Participants reported moderate functional limitations (M ± SD = 52.7 ± 9.0). Comorbidities were low (1.7 ± 1.5; range = 0-7). The middle-aged group experienced a greater number of total symptoms (21.4 ± 5.9 vs. 19.3 ± 5.2; p < .01).
Discussion:
Middle-aged adults with fibromyalgia were more symptomatic than older adults. Further study is needed to understand the relationship between fibromyalgia symptoms and age and physical function.
Related Concept Videos
Menopause
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
The Effect of Aging on Tissues
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Geriatric Patients
