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Updated: May 29, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Integrating developmental signals: a Hippo in the (path)way.
A Mauviel1, F Nallet-Staub, X Varelas
1Institut Curie, Centre de Recherche, Orsay, France. alain.mauviel@curie.fr
Oncogene
|August 30, 2011
Summary
The Hippo pathway regulates cell growth and differentiation. This review explores its integration with other signaling pathways, revealing new biological roles.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The Hippo pathway is a crucial regulator of cell proliferation, apoptosis, and differentiation.
- It plays a fundamental role in numerous physiological and pathological processes.
- Recent research indicates complex interactions within the Hippo pathway network.
Purpose of the Study:
- To review recent findings in Hippo pathway research.
- To emphasize the integration of the Hippo pathway with other signaling cascades.
- To highlight novel roles of Hippo signaling.
Main Methods:
- Literature review of recent studies on the Hippo pathway.
- Analysis of signaling pathway crosstalk.
- Synthesis of current knowledge on Hippo pathway regulation.
Main Results:
- The Hippo pathway interacts with a complex network of signaling molecules.
- Crosstalk with pathways like TGFβ/SMAD and WNT/β-catenin has been identified.
- These interactions reveal novel functions of Hippo signaling.
Conclusions:
- The Hippo pathway is extensively integrated with other key signaling pathways.
- This integration is essential for mediating diverse biological processes.
- Understanding Hippo pathway crosstalk offers new therapeutic avenues.
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