Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter Assessment of Combined Brain and Cervical Spinal cord 3T MP2RAGE T1 Measurements for Reliable Tissue Microstructure Quantification.

NMR in biomedicine·2026
Same author

Automatic multiple sclerosis lesion segmentation in the spinal cord using 3 T and 7 T MP2RAGE images.

Multiple sclerosis and related disorders·2026
Same author

Motor tract lesion mapping from the brain to the lower spinal cord in people with relapsing-remitting multiple sclerosis: exploring the association between lesion severity and functional consequences by limb.

Brain communications·2026
Same author

SNR-Efficient Inhomogeneous Magnetization Transfer (ihMT) for Clinical Applications at 7 T.

Magnetic resonance in medicine·2026
Same author

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS.

Annals of clinical and translational neurology·2026
Same author

Segmentation of spinal rootlets across MRI contrasts with RootletSeg.

Scientific reports·2026

Related Experiment Video

Updated: May 29, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Cerebral perfusion MRI in mice.

Frank Kober1, Guillaume Duhamel, Virginie Callot

  • 1Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR 6612, CNRS, Université de la Méditerranée, 13385 Marseille Cedex 05, France. frank.kober@univmed.fr

Methods in Molecular Biology (Clifton, N.J.)
|August 30, 2011
PubMed
Summary
This summary is machine-generated.

Arterial spin labeling (ASL) MRI quantifies rodent cerebral blood flow (CBF), aiding research into human diseases. This technique is valuable for studying microvascular dysfunction in various murine models.

More Related Videos

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
12:15

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining
09:40

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining

Published on: November 6, 2012

Related Experiment Videos

Last Updated: May 29, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
12:15

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining
09:40

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining

Published on: November 6, 2012

Area of Science:

  • Neuroimaging
  • Physiology
  • Biomedical Engineering

Background:

  • Perfusion MRI assesses microvascular blood flow distribution.
  • Arterial spin labeling (ASL) offers advantages for quantifying cerebral blood flow (CBF) in rodents.
  • ASL is suitable for evaluating murine models of human pathology, particularly those with diffuse microvascular dysfunction.

Purpose of the Study:

  • Introduce the principles of CBF measurement using MRI.
  • Provide an overview of ASL applications in research.
  • Equip readers with the knowledge to set up post-processing tools for ASL data.

Main Methods:

  • Describe the basics of commonly used ASL techniques.
  • Outline the underlying theory for ASL measurements.
  • Detail three MR protocols for pulsed ASL on different MRI systems, including parameters and requirements.

Main Results:

  • Discuss the significance of various theoretical parameters in ASL.
  • Provide specific steps for animal preparation and maintenance during experiments.
  • Highlight the sensitivity of CBF regulation to physiological parameters like anesthesia and body temperature.

Conclusions:

  • ASL MRI is a powerful tool for quantifying rodent CBF.
  • The technique is applicable to diverse murine models of human diseases.
  • Understanding ASL principles and experimental parameters is crucial for accurate results.