Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

2D NMR: Overview of Homonuclear Correlation Techniques

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...

2D NMR: Overview of Heteronuclear Correlation Techniques

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...

¹H NMR: Long-Range Coupling

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spin polarization transfer from laser-polarized <sup>129</sup>Xe to oxygen-sensitive perfluorocarbons at ultra-low magnetic field.

Scientific reports·2025

Same author

Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized <sup>129</sup>Xe.

Communications medicine·2023

Same author

Background-Free Detection of Spin-Exchange Dynamics at Ultra-Low Magnetic Field.

Chemphyschem : a European journal of chemical physics and physical chemistry·2023

Same author

Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.

Frontiers in endocrinology·2020

Same author

Comparison of single breath hyperpolarized <sup>129</sup> Xe MRI with dynamic <sup>19</sup> F MRI in cystic fibrosis lung disease.

Magnetic resonance in medicine·2020

Same author

Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop.

Magnetic resonance in medicine·2019

Search research articles

Related Experiment Video

Updated: May 29, 2026

Quantifying Mixing using Magnetic Resonance Imaging

Quantifying Mixing using Magnetic Resonance Imaging

Published on: January 25, 2012

MRI using intermolecular multiple-quantum coherences.

Rosa Tamara Branca¹

¹Department of Chemistry, Duke University, Durham, NC 27708, USA. rtb9@duke.edu

Methods in Molecular Biology (Clifton, N.J.)

|August 30, 2011

Summary

Intermolecular multiple-quantum coherences (iMQCs) generate NMR signals from weak dipolar interactions. This chapter details iMQC methods for optimizing signals in applications like MRI and spectroscopy.

Area of Science:

Nuclear Magnetic Resonance (NMR) spectroscopy
Quantum coherence phenomena

Background:

Intermolecular multiple-quantum coherences (iMQCs) enable detection of weak dipolar interactions between distant spins in solution.
Recent advancements have expanded iMQC applications in magnetic resonance imaging (MRI) and high-resolution spectroscopy.
Established applications include MRI contrast enhancement, suppression of NMR signal broadening, and in vivo temperature measurement.

Purpose of the Study:

To elucidate the fundamental principles of basic intermolecular multiple-quantum coherence (iMQC) pulse sequences.
To provide guidance on selecting sequence parameters for signal optimization.
To address strategies for mitigating signal contamination in iMQC experiments.

Main Methods:

Description of fundamental iMQC pulse sequence mechanisms.

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Related Experiment Videos

Last Updated: May 29, 2026

Quantifying Mixing using Magnetic Resonance Imaging

Quantifying Mixing using Magnetic Resonance Imaging

Published on: January 25, 2012

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Discussion of parameter selection for enhancing iMQC signal intensity.

Methods for overcoming signal contamination in iMQC measurements.

Main Results:

Understanding the operational principles of iMQC pulse sequences.
Identification of key parameters for optimizing iMQC signal-to-noise ratio.
Strategies for distinguishing and removing unwanted signal contributions.

Conclusions:

iMQCs are powerful tools for detecting subtle spin interactions in solution-state NMR.
Optimized iMQC sequences enhance performance in diverse applications like MRI and spectroscopy.
Effective parameter selection and contamination suppression are crucial for reliable iMQC data acquisition.