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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...

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Related Experiment Video

Updated: May 29, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Published on: September 3, 2013

Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging.

Roel Straathof1, Gustav J Strijkers, Klaas Nicolay

  • 1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. r.straathof@tue.nl

Methods in Molecular Biology (Clifton, N.J.)
|August 30, 2011
PubMed
Summary

Accurate disease diagnosis relies on molecular imaging. Researchers developed targeted lipid-based micelles as versatile contrast agents for molecular MRI and other imaging modalities, improving in vivo visualization of cellular processes.

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Last Updated: May 29, 2026

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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Timely and accurate disease diagnosis is crucial for effective treatment.
  • Molecular imaging enables non-invasive visualization of cellular functions and molecular processes in vivo.
  • Targeted contrast agents are essential for molecular magnetic resonance imaging (MRI).

Purpose of the Study:

  • To develop powerful, targeted contrast agents for molecular MRI.
  • To create versatile lipid-based nanoparticles for enhanced in vivo imaging.
  • To explore the potential of micelles as multi-modal imaging contrast agents.

Main Methods:

  • Development of gadolinium-containing paramagnetic and superparamagnetic iron oxide-based micelles.
  • Functionalization of micelles with high-affinity ligands for target specificity.
  • Incorporation of contrast-generating molecules for fluorescence and nuclear imaging.

Main Results:

  • Created biocompatible, lipid-based micelles with high payload of MR contrast agents.
  • Achieved target-specific molecular imaging through ligand coupling.
  • Demonstrated versatility by incorporating contrast agents for multiple imaging modalities.

Conclusions:

  • Lipid-based micelles represent a highly versatile platform for molecular imaging contrast agents.
  • Targeted micelles enhance the precision of in vivo diagnosis.
  • This platform facilitates multi-modal imaging, offering broad applications in disease detection and research.