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Related Experiment Video

Updated: May 29, 2026

In Vitro Canine Neutrophil Extracellular Trap Formation: Dynamic and Quantitative Analysis by Fluorescence Microscopy
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Published on: August 24, 2018

[Pentraxin 3].

Kenji Inoue1

  • 1Department of Cardiology, Juntendo University Nerima Hospital, Nerima-ku, Tokyo 177-8521, Japan. inouelsbm@yahoo.co.jp

Rinsho Byori. the Japanese Journal of Clinical Pathology
|August 31, 2011
PubMed
Summary
This summary is machine-generated.

Pentraxin 3 (PTX3) is a novel biomarker for inflammatory vascular disease. In acute coronary syndrome (ACS), neutrophils infiltrating thrombi are a key source of PTX3, aiding diagnosis.

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Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Context:

  • Pentraxin 3 (PTX3) is a recently recognized protein within the pentraxin family, distinct from C-reactive protein (CRP).
  • PTX3 is expressed in atherosclerotic lesions by various cells, including macrophages and neutrophils.
  • Pitavastatin has been shown to suppress PTX3 gene expression in human endothelial cells.

Purpose:

  • To investigate the source of elevated PTX3 levels in patients with acute coronary syndrome (ACS).
  • To determine if PTX3 can serve as a diagnostic biomarker for inflammatory vascular diseases like ACS.
  • To identify the specific cells responsible for PTX3 production at the site of plaque rupture.

Summary:

  • Blood samples were collected from the site of plaque rupture in 114 ACS patients undergoing PCI.
  • Immunohistochemical analysis of aspirated thrombi identified infiltrating neutrophils as the primary source of PTX3.
  • PTX3 levels in ACS patients are significantly influenced by neutrophil infiltration within thrombi.

Impact:

  • Neutrophils within thrombi are a diagnostically important source of PTX3 in ACS patients.
  • This finding enhances understanding of PTX3's role in acute inflammatory vascular events.
  • PTX3 shows potential as a specific biomarker for diagnosing ACS and related inflammatory vascular conditions.