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Updated: May 29, 2026

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
10:43

Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein

Published on: December 3, 2010

[Molecular physiology of receptor mediated endocytosis and its role in overcoming multidrug resistance]

E S Severin, G A Posypanova

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |August 31, 2011
    PubMed

    Insights

    Receptor-mediated endocytosis facilitates selective protein uptake in cells. This process can be leveraged for targeted drug delivery, enhancing selectivity and overcoming multidrug resistance.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Pharmacology

    Background:

    • Receptor-mediated endocytosis is crucial for selective protein uptake at the eukaryotic cell plasma membrane.
    • Endocytosis regulates cell signaling by controlling cell surface receptor numbers.

    Purpose of the Study:

    • To review the mechanism of clathrin-dependent endocytosis.
    • To explore the potential of endocytosis for targeted drug delivery.

    Main Methods:

    • Review of scientific literature on clathrin-dependent endocytosis.
    • Analysis of drug delivery system strategies utilizing receptor-mediated endocytosis.

    Main Results:

    • Clathrin-dependent endocytosis provides a mechanism for targeted cellular uptake.
    • Incorporating targeting proteins into drug delivery systems enhances drug selectivity.
    • This approach can overcome multidrug resistance mediated by ABC-transporters.

    Conclusions:

    • Clathrin-dependent endocytosis is a viable mechanism for targeted drug delivery.
    • Targeted delivery systems can improve therapeutic efficacy and combat drug resistance.

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