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Published on: July 19, 2018
Endothelial dysfunction in uremic patients on continuous ambulatory peritoneal dialysis (CAPD)
Senija Rašić1, Almira Hadžović-Džuvo, Damir Rebić
1Clinic of Nephrology, University of Sarajevo Clinical Center, Bosnia and Herzegovina. rasicnef@bih.net.ba
Bosnian Journal of Basic Medical Sciences
|August 31, 2011
Summary
Diabetic patients on continuous ambulatory peritoneal dialysis (CAPD) show significant endothelial dysfunction and increased cardiovascular risk compared to non-diabetic CAPD patients. Biomarkers indicate systemic alterations contributing to this higher risk.
Area of Science:
- Nephrology
- Cardiology
- Endocrinology
Background:
- Endothelial dysfunction is linked to diabetic complications and declining kidney function.
- Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) may experience endothelial dysfunction.
Purpose of the Study:
- To investigate plasma biomarkers of endothelial dysfunction in CAPD patients.
- To assess the association between these biomarkers and carotid artery intima-media thickness (IMT) in diabetic versus non-diabetic CAPD patients.
Main Methods:
- Study included 37 CAPD patients (25 with type 2 diabetes, 12 non-diabetic).
- Measured plasma biomarkers: von Willebrand factor (vWF) activity, albumin, glucose, lipids (cholesterol, triglycerides, Lp(a)), homocysteine, parathyroid hormone (PTH).
- Assessed carotid intima-media thickness (IMT) using ultrasound.
Main Results:
- Mean IMT was significantly higher in diabetic CAPD patients (0.86 mm) vs. non-diabetic (0.52 mm) (p<0.0001).
- Diabetic patients exhibited significant differences in lipid profiles, procoagulation factors (vWF, Factor VIII), and inflammatory markers (CRP).
- Log triglycerides and Factor VIII were independent predictors of IMT.
Conclusions:
- Diabetic type 2 CAPD patients exhibit systemic endothelial dysfunction.
- These patients face a higher risk of cardiovascular complications compared to non-diabetic CAPD patients.
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