Related Experiment Video
Updated: May 29, 2026

High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet's disease
Burçak Vural1, Elif Uğurel, Erdem Tüzün
1Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
Abstract:
No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.
Related Concept Videos
Encephalitis ll: Pathophysiology
Neural Regulation
Bacterial Meningitis II: Pathophysiology

