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Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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Measuring pacemaker dose: a clinical perspective.

Matthew T Studenski1, Ying Xiao, Amy S Harrison

  • 1Department of Radiation Oncology at the Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. matthew.studenski@jeffersonhospital.org

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
|August 31, 2011
PubMed
Summary
This summary is machine-generated.

Accurate dosimetry for pacemakers and defibrillators is crucial. MOSFETs and diodes are efficient choices for measuring radiation dose, but treatment plans with lateral beams require careful review.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Dosimetry

Background:

  • Increasing number of patients with implanted cardiac devices (pacemakers and defibrillators) undergoing radiation therapy.
  • Potential adverse effects of radiation on device electronics necessitate careful dose minimization.
  • Need for accurate and efficient dosimetry methods to measure device dose in clinical workflows.

Purpose of the Study:

  • To evaluate and compare the accuracy of different dosimeters for measuring radiation dose to pacemakers and defibrillators.
  • To determine the most suitable dosimeter for maintaining an efficient clinical workflow.
  • To assess dosimeter performance considering angular and energy dependence, and clinical case scenarios.

Main Methods:

  • Analysis of ion chambers, diodes, metal-oxide-semiconductor field-effect transistors (MOSFETs), and optically stimulated luminescence (OSL) dosimeters.
  • Quantification of angular and energy dependence using a simple phantom.
  • Comparison of dosimeter measurements with predicted doses in a Rando phantom for 8 patient plans, including CBCT imaging for kilovoltage energy range response.

Main Results:

  • Ion chambers and diodes demonstrated the most stability regarding angular and energy dependence.
  • All analyzed dosimeters showed good agreement with predicted doses in clinical cases, though accuracy varied.
  • MOSFETs and diodes showed reduced accuracy with lateral beams; ion chambers and diodes were most stable.

Conclusions:

  • MOSFETs or diodes are recommended for efficient dose measurement due to their efficiency.
  • Case dependency dictates the ideal dosimeter; careful review of treatment plans with lateral beams is advised for discrepancies.
  • Post-CBCT acquisition placement of dosimeters and using alternative dosimeter types for follow-up are recommended.