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Related Concept Videos

Transport Across the Golgi01:26

Transport Across the Golgi

While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
Golgi Apparatus01:49

Golgi Apparatus

As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...

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Related Experiment Video

Updated: May 29, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

Models for Golgi traffic: a critical assessment.

Benjamin S Glick1, Alberto Luini

  • 1Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA. bsglick@uchicago.edu

Cold Spring Harbor Perspectives in Biology
|August 31, 2011
PubMed
Summary

Current models for Golgi traffic are debated. Cisternal progression/maturation is proposed as a conserved core mechanism, potentially enhanced by heterotypic tubular transport in some cells.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The Golgi apparatus is crucial for modifying and sorting proteins and lipids.
  • Understanding the precise mechanisms of intra-Golgi transport remains a significant challenge in cell biology.

Purpose of the Study:

  • To critically evaluate five prominent models of Golgi apparatus traffic.
  • To determine the most plausible conserved mechanism for secretory cargo transport through the Golgi.

Main Methods:

  • Comparative analysis of five distinct Golgi traffic models.
  • Assessment of each model against a comprehensive set of key experimental observations from various cell types and organisms.

Main Results:

  • No single model fully explains all observed phenomena of Golgi traffic across diverse species.
  • The cisternal progression/maturation model demonstrates the strongest explanatory power for core Golgi functions.

Conclusions:

  • Cisternal progression/maturation is the most likely conserved fundamental mechanism for Golgi transport.
  • Heterotypic tubular transport may represent a specialized elaboration of the core mechanism in certain cellular contexts.