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Two-year vascular event rates in patients with symptomatic cerebrovascular disease: the REACH registry

Narayanaswamy Venketasubramanian1, Joachim Röther, Deepak L Bhatt

  • 1Division of Neurology, National University Hospital, Singapore.

Cerebrovascular Diseases (Basel, Switzerland)
|August 31, 2011
PubMed

Insights

Patients with symptomatic cerebrovascular disease (CeVD) face high rates of vascular events, including stroke and cardiovascular death, within two years. Recurrent strokes are more frequent than heart attacks in this high-risk group.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Clinical Research

Background:

  • Vascular outcome data in cerebrovascular disease (CeVD) patients are limited in practice-based studies.
  • The REduction of Atherothrombosis for Continued Health (REACH) Registry provides a platform for such research.

Purpose of the Study:

  • To report 2-year vascular outcomes in symptomatic CeVD patients.
  • To identify predictors of vascular events in this population.

Main Methods:

  • Prospective cohort study of stable outpatients with established atherothrombosis or multiple risk factors.
  • Analysis of vascular events including stroke, myocardial infarction (MI), cardiovascular death, and hospitalizations.
  • Inclusion of 18,189 symptomatic CeVD patients from the REACH Registry.

Main Results:

  • At 2 years, symptomatic CeVD patients experienced a 5.93% rate of non-fatal stroke and 4.45% cardiovascular death.
  • The combined vascular endpoint occurred in 11.48% of patients.
  • Patients with CeVD, coronary artery disease, and peripheral artery disease had the highest event rates.
  • Age, diabetes, smoking, and carotid disease were predictors of vascular events.

Conclusions:

  • Symptomatic CeVD patients exhibit high vascular event rates despite ongoing treatment.
  • Non-fatal recurrent stroke is a more prevalent event than non-fatal myocardial infarction in this cohort.
Abstract

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