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Updated: May 29, 2026

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
Published on: November 11, 2022
Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders
1Department of Pediatrics, Neurology, Sainte-Justine Hospital and Research Center, 3175 Chemin de la Côte Sainte-Catherine, Montreal, QC, Canada. elsa.rossignol@umontreal.ca
Abstract:
A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders. Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders.
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