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Updated: May 29, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal
Cahide Gökkuşu1, Zeynep Özbek, Gülten Tata
1Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey. cahgok@istanbul.edu.tr
Objectives:
Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT).
Design And Methods:
In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of postmenopausal receiving (2 mg estrodiol valerate + 1 mg cyproterone acetate) HRT group, the remaining 25 received orally placebo (NHRT group).
Results:
There was no significant change in plasma tHcy levels between HRT and NHRT groups. Malondialdehyde (MDA) and total thiol (t-SH) correlated significantly with tHcy (0.388 and 0.478, respectively) content, and there was a significant negative correlation between E2 level and glutathione transferase (GST) activity (-0.425) in HRT group. Superoxide dismutase (SOD) and HDL-C correlated significantly with t-SH level (0.339 and 0.336, respectively) in plasma after HRT.
Conclusion:
Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.
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