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Updated: May 29, 2026

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

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Published on: August 19, 2016

Streptococcus pyogenes bacteraemia, emm types and superantigen profiles.

S Rantala¹, S Vähäkuopus, T Siljander

¹Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland. sari.rantala@uta.fi

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology

|August 31, 2011

Summary

This study analyzed 87 invasive Streptococcus pyogenes (group A streptococcal) isolates in Finland, finding no link between emm types or superantigen profiles and disease severity. A potential vaccine showed limited coverage for these invasive strains.

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Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test

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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

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Published on: August 19, 2016

Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test

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Published on: July 14, 2023

Area of Science:

Microbiology
Infectious Diseases
Epidemiology

Background:

Group A Streptococcus (GAS), or Streptococcus pyogenes, causes invasive infections.
Understanding molecular characteristics like emm types and superantigen profiles is crucial for tracking and managing GAS epidemiology.
Previous studies have explored associations between GAS virulence factors and clinical outcomes.

Purpose of the Study:

To investigate the emm types and superantigen profiles of bacteraemic GAS isolates.
To determine if molecular characteristics correlate with clinical presentations of invasive disease.
To assess the potential coverage of a 26-valent GAS vaccine against local isolates.

Main Methods:

Population-based study of 87 bacteraemic GAS isolates from adult patients in Finland (1995-2004).
emm typing and genotyping for superantigen (SAg) profiles.
Analysis of epidemiological and clinical data alongside microbiological characterization.

Main Results:

18 different emm types were identified, with emm1, emm28, and emm81 being the most common (52%).
No significant association was found between emm type and clinical features (underlying diseases, manifestations, case fatality).
speA and speC genes were present in 20% and 30% of strains, respectively, with no link to disease manifestation. A 26-valent vaccine would cover only 62% of isolates.

Conclusions:

emm type and superantigen profiles of bacteraemic GAS isolates in this Finnish population showed variability but no clear association with clinical disease presentation or severity.
The identified emm types and SAg profiles suggest limited efficacy for the evaluated 26-valent GAS vaccine in this region during the study period.
Further research is needed to understand the complex interplay between GAS molecular epidemiology and invasive disease outcomes.