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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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The CDK inhibitors in cancer research and therapy

Jonas Cicenas1, Mindaugas Valius

  • 1Department of Medicine, Institute of Anatomy, University of Fribourg, Rte. Albert- Gockel 1, 1700, Fribourg, Switzerland. j.cicenas@mapkinases.eu

Journal of Cancer Research and Clinical Oncology
|August 31, 2011
PubMed

Insights

This review discusses seventeen small-molecule cyclin-dependent kinase (CDK) inhibitors, detailing their targets, availability, and efficacy. It aids researchers in selecting appropriate CDK inhibitors for cancer research and therapeutic applications.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Kinase inhibitors are crucial tools for understanding mammalian cell biochemical processes.
  • Cyclin-dependent kinases (CDKs) regulate cell cycle and proliferation, with deregulation implicated in human tumors and various diseases.

Purpose of the Study:

  • To review seventeen small-molecule CDK inhibitors for their utility in cancer research and therapy.
  • To guide researchers in selecting the most suitable CDK inhibitor for their specific research needs.

Main Methods:

  • Compilation and discussion of seventeen CDK inhibitors.
  • Inclusion of inhibitor targets, commercial availability, and IC(50) values.
  • Overview of clinical studies involving selected CDK inhibitors.

Main Results:

  • Detailed information on seventeen CDK inhibitors is presented.
  • Data on targets, IC(50) values, and commercial availability are provided for each inhibitor.
  • Clinical study data for some inhibitors are summarized.

Conclusions:

  • The review provides a comprehensive resource for researchers investigating CDK inhibitors.
  • Informed selection of CDK inhibitors is facilitated for both research and therapeutic development.
  • Understanding inhibitor profiles aids in advancing cancer research and treatment strategies.

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