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Familial lichen planus.

V Katzenelson1, M Lotem, M Sandbank

  • 1Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.

Dermatologica
|January 1, 1990
PubMed
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Familial lichen planus (FLP) shows a genetic predisposition, with affected family members exhibiting a mild disease course and rapid response to topical steroids. Human Leukocyte Antigen (HLA) DR typing was positive in all three patients.

Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Background:

  • Familial lichen planus (FLP) is a rare variant of lichen planus.
  • Understanding the genetic factors and clinical presentation of FLP is crucial for diagnosis and management.

Observation:

  • Three cases of familial lichen planus (FLP) are presented, involving two sisters and one of their sons.
  • The disease onset occurred within a 3-year period.
  • Clinical presentation varied, with generalized eruption in only one patient and no atypical forms observed.

Findings:

  • The patients experienced a rapid response to topical steroid treatment.
  • Relapses were infrequent and mild.
  • Human Leukocyte Antigen (HLA) typing revealed HLA DR in all three affected individuals.

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  • No increased incidence of HLA B7, HLA A3, or HLA A28 was noted.

    • Implications:

    • The findings support a genetic predisposition in familial lichen planus.
    • The mild clinical course and favorable treatment response in this family suggest specific genetic or immunologic factors may influence disease severity.
    • Further research into HLA associations in FLP is warranted.