Related Experiment Video
Updated: May 29, 2026

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine
Mário Rodrigues de Melo Filho1, Célsia Adriane Dias da Silva, Maurício da Rocha Dourado
1Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
Abstract:
The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.
More Related Videos
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Malaria
Jaundice
Diversity of Protists II
Antiprotozoal Agents

