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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

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Predictive Immune Modeling of Solid Tumors
08:50

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Published on: February 25, 2020

Predictive genomic biomarkers.

Rakesh Kumar1, Rafael G Amado

  • 1Oncology Research and Development, GlaxoSmithKline, Collegeville, PA 19426, USA.

Current Topics in Microbiology and Immunology
|August 31, 2011
PubMed
Summary
This summary is machine-generated.

Targeted anticancer agents require specific molecular alterations for efficacy. This review examines selection markers, drug-diagnostic co-development, and personalized oncology strategies for improved cancer treatment.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Tumor biological characterization has advanced anticancer agent development.
  • Many agents target phosphorylation signals crucial for cancer progression.
  • Identifying specific molecular alterations is key for targeted therapies.

Purpose of the Study:

  • To review the use of selection markers in oncology.
  • To discuss co-development of drugs and diagnostics.
  • To explore future directions in personalized oncology.

Main Methods:

  • Literature review of selection markers in cancer treatment.
  • Analysis of drug-diagnostic co-development considerations.
  • Discussion of regulatory pathways and late-emerging markers.

Main Results:

  • Selection markers are crucial for identifying patient subsets for targeted therapies.
  • Co-development of drugs and diagnostics streamlines therapeutic programs.
  • Personalized oncology relies on effective marker selection and validation.

Conclusions:

  • Effective use of selection markers enhances therapeutic benefits and trial efficiency.
  • Co-development strategies are vital for the success of targeted anticancer agents.
  • Future personalized oncology will increasingly integrate predictive biomarkers and targeted treatments.