Related Experiment Video
Updated: May 29, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
[Cannabinoid hyperemesis syndrome inducing acute prerenal failure and electrolyte disturbance]
1Medizinische Klinik II, Kardiologie und Nephrologie, Klinikum Bremerhaven Reinkenheide, Bremerhaven. joern.bramstedt@klinikum-bremerhaven.de
History And Clinical Findings:
A 36-year-old patient presented to the psychiatric clinic with presumed worsening of a chronic psychosis.
Investigations:
Laboratory values revealed acute renal failure and electrolyte imbalance. A further diagnostic work-up including urine analysis as well as abdominal und retroperitoneal sonography was normal.
Diagnosis, Therapy And Clinical Course:
By exact history taking the clinical diagnosis of a cannabinoid hyperemesis syndrome (CHS) was established. Symptomatic treatment with intravenous fluids and electrolytes together with strict cannabis abstinence completely resolved all symptoms and normalized all pathologic values.
Conclusion:
Recreational use of cannabis is widespread. It may induce a widely unknown syndrome characterized by nausea, vomiting and crampy abdominal pain accompanied by frequent hot showers or bathing. This syndrome should be recognized as a potential cause of acute prerenal failure.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chronic Kidney Disease II: Clinical Manifestations
Acute Pancreatitis II: Pathophysiology
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Acute Pancreatitis I: Introduction
