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[Bone disease in chronic renal failure and its modern therapy]

S Dusilová Sulková1

  • 1Klinika nefrologie, Transplantacní centrum IKEM Praha. sulkovas@volny.cz

Vnitrni Lekarstvi
|September 1, 2011
PubMed

Insights

Secondary hyperparathyroidism, a complication of chronic renal failure, impacts bone and cardiovascular health. Treatment focuses on correcting hyperphosphatemia and parathyroid gland activity using phosphate binders, calcimimetics, and vitamin D receptor activators.

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Renal bone disease is a severe complication of chronic kidney disease (CKD).
  • Secondary hyperparathyroidism is a key factor in its development.
  • CKD-MBD links bone disease and cardiovascular issues in renal patients.

Purpose of the Study:

  • To outline current prevention and treatment strategies for renal bone disease.
  • To highlight the interplay between bone and cardiovascular complications in CKD.
  • To discuss the role of specific drug classes in managing CKD-MBD.

Main Methods:

  • Review of pathogenetic and clinical interrelationships in CKD-MBD.
  • Focus on correcting hyperphosphatemia and parathyroid gland overactivity.
  • Utilizing vitamin D receptor (VDR) and calcium receptor (CaR) modulation.

Main Results:

  • Treatment prioritizes correcting hyperphosphatemia.
  • Subsequent management targets parathyroid gland reactivity.
  • Key drug classes include GIT phosphate binders, calcimimetics, and VDR activators.

Conclusions:

  • Effective management of CKD-MBD requires addressing both bone and cardiovascular aspects.
  • Pharmacological interventions targeting VDR and CaR are crucial.
  • Specific therapies exist for refractory cases and calciphylaxis.

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