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Updated: May 29, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
[Anemia and chronic kidney failure]
1Centrum kardiovaskulární a transplantacní chirurgie Brno. sona.stepankova@cktch.cz
Abstract:
Anaemia is a common manifestation ofa chronic kidney failure. It is caused by a relative shortage oferythropoetine (EPO) and iron deficite with its metabolism defect. The most important factor in the pathogenesis of iron metabolism defects is hepcidin. Hepcidin maintains the iron homeostasis in the organism. The therapy of renal anaemia is based on the iron substitution and erythropoiesis stimulating agents (ESA) application. The most common reasons for the resistance to ESA are (after iron deficiency) inflammation and malnutrition.
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