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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii
Emma C Barnes1, Anthony R Carroll, Rohan A Davis
1Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Abstract:
Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien-15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.
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