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Updated: May 29, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

Prevention of contrast-induced nephropathy with haemofiltration in high-risk patients after percutaneous coronary

J R Rey1, D Iglesias, E López De Sá

  • 1La Paz University Hospital, Cardiology, Madrid, Spain. jreyblas@hotmail.com

Acute Cardiac Care
|September 1, 2011
PubMed

Insights

Prophylactic haemofiltration (PHF) significantly reduced contrast-induced nephropathy (CIN) in high-risk patients undergoing percutaneous coronary intervention (PCI). This intervention shows promise in preventing kidney damage after PCI procedures.

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • Contrast-induced nephropathy (CIN) incidence is rising post-percutaneous coronary intervention (PCI).
  • High-risk patients undergoing PCI are particularly susceptible to CIN.
  • Identifying effective preventative strategies for CIN is crucial.

Purpose of the Study:

  • To evaluate the efficacy of prophylactic haemofiltration (PHF) in preventing CIN.
  • To assess the benefits of PHF in high-risk patients undergoing PCI.
  • To compare CIN incidence between patients receiving PHF and controls.

Main Methods:

  • Retrospective analysis of 20 patients who underwent PHF post-PCI for acute coronary syndrome.
  • Comparison with 20 matched control patients with similar risk factors.
  • Analysis of CIN incidence, acute kidney failure, heart failure, and mortality.

Main Results:

  • The PHF group showed a significantly lower incidence of CIN (30%) compared to the control group (65%, P=0.03).
  • Baseline characteristics, including creatinine, contrast volume, and Mehran score, were similar between groups.
  • No significant differences were observed in other secondary outcomes like acute kidney failure, heart failure, or mortality.

Conclusions:

  • Prophylactic haemofiltration (PHF) appears to be an effective strategy for preventing CIN.
  • PHF may reduce the risk of kidney injury in high-risk patients undergoing PCI.
  • Further prospective studies are warranted to confirm these findings.
Abstract

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