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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
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Three-dimensional biomaterials for the study of human pluripotent stem cells

Thomas P Kraehenbuehl1, Robert Langer, Lino S Ferreira

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nature Methods
|September 1, 2011
PubMed

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...