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Related Concept Videos

Maturation of Endosomes01:28

Maturation of Endosomes

The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

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Related Experiment Video

Updated: May 29, 2026

Study of Phagolysosome Biogenesis in Live Macrophages
08:06

Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 10, 2014

Endosome maturation.

Jatta Huotari1, Ari Helenius

  • 1Institute of Biochemistry, ETH Zurich, Switzerland.

The EMBO Journal
|September 1, 2011
PubMed
Summary
This summary is machine-generated.

Endocytic processes are crucial for cell life and disease, impacting signalling, growth, and defence. This review details endosome maturation into late endosomes/multivesicular bodies, preparing them for lysosomal pathways.

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In Vitro Polymerization of F-actin on Early Endosomes
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In Vitro Polymerization of F-actin on Early Endosomes

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Last Updated: May 29, 2026

Study of Phagolysosome Biogenesis in Live Macrophages
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Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 10, 2014

In Vitro Polymerization of F-actin on Early Endosomes
12:15

In Vitro Polymerization of F-actin on Early Endosomes

Published on: August 28, 2017

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Endocytic processes are fundamental to cellular functions, including signalling, dynamics, growth, regulation, and defence.
  • These processes are implicated in numerous aspects of cell life and disease.

Purpose of the Study:

  • To review the endosome maturation programme within the classical endocytic pathway.
  • To describe the transformation of organelles leading to late endosomes/multivesicular bodies.

Main Methods:

  • Literature review focusing on endosome maturation.
  • Analysis of the functional and spatial changes during organelle transformation.

Main Results:

  • Endosome maturation involves significant transformations, leading to the formation of late endosomes/multivesicular bodies.
  • These late endosomes become functionally and spatially distinct from early endosomes.

Conclusions:

  • The maturation of late endosomes/multivesicular bodies is a critical step in the endocytic pathway.
  • These organelles serve as a feeder pathway to lysosomes, essential for cellular waste disposal and recycling.